Detransitioners Michelle, Laura, Cat, David, Joel and Abel tell the stories of their gender distress, transgender medicalization, and subsequent detransition. Without diagnostic clarity or mental health evaluations, their doctors quickly affirmed them as “transgender,” and mindlessly ushered them along the path of medical transition. (The “gender-affirming care” is the only treatment recommended by the American Academy of Pediatrics.) These young people were harmed irrevocably by the doctors they trusted. AFFIRMATION GENERATION demonstrates how the “one-size-fits-all” medicalization – the “gender-affirming care” – has failed these patients.